Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrus fruits, particularly their flavonoid components like hesperidin and diosmin, have scientific evidence supporting their use in supporting the venous system. These flavonoids are found in the peels and pulps of citrus fruits such as oranges, lemons, and grapefruits. Clinical studies have demonstrated that purified flavonoid fractions from citrus, especially diosmin and hesperidin, can improve symptoms related to chronic venous insufficiency (CVI), including leg swelling, pain, and heaviness. For example, a systematic review published in Phytotherapy Research (2018) found that micronized purified flavonoid fraction (MPFF), which contains diosmin and hesperidin, significantly improved venous tone and reduced capillary permeability in patients with CVI and varicose veins. The proposed mechanisms include strengthening capillary resistance, reducing inflammation, and improving lymphatic drainage. These effects have led to the inclusion of citrus-derived flavonoid supplements in guidelines for the management of CVI in some countries. While whole citrus fruit consumption provides lower concentrations of these flavonoids compared to pharmaceutical preparations, the scientific validation for their use in venous support is primarily linked to these specific extract forms.

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