Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Centella triterpenes, derived from the plant Centella asiatica (commonly known as gotu kola), have been used in both traditional medicine and modern phytotherapy to support venous health. Scientific studies have investigated the efficacy of Centella triterpenes—primarily asiaticoside, madecassoside, and asiatic acid—in chronic venous insufficiency (CVI) and related vein disorders. Clinical trials and pharmacological research have shown that Centella triterpenes can improve microcirculation, reduce capillary filtration rate, and decrease edema in patients with CVI. These effects are thought to result from strengthening of the vascular connective tissues and modulation of collagen synthesis, which help reduce venous hypertension and associated symptoms such as swelling, heaviness, and pain in the legs.

A number of double-blind, placebo-controlled studies (such as Cospite et al., 1991; Cesarone et al., 1992; Incandela et al., 2001) have reported statistically significant improvements in objective and subjective measures in patients treated with Centella triterpenes compared to placebo. The European Medicines Agency also recognizes Centella triterpenes for their use in treating symptoms of chronic venous insufficiency. However, while evidence is promising, the majority of studies are relatively small and further large-scale, high-quality trials are warranted to confirm long-term efficacy and safety. Thus, the scientific evidence base is moderate (rated 3/5), indicating meaningful support for the use of Centella triterpenes in venous health, but not yet conclusive.

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