Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bioflavonoids, a diverse group of plant-derived compounds also known as flavonoids, have been traditionally used and scientifically investigated for their effects on vascular health, particularly within the veins. Scientific research has shown that certain bioflavonoids, especially those found in citrus fruits such as diosmin and hesperidin, can strengthen capillary walls, reduce capillary permeability, and improve venous tone. These effects are believed to help in the management of chronic venous insufficiency (CVI), varicose veins, and hemorrhoids.

Clinical studies support the use of micronized purified flavonoid fraction (MPFF), which consists mainly of diosmin and hesperidin, in reducing symptoms of CVI, such as leg swelling, pain, and heaviness. The European Medicines Agency recognizes the traditional and clinical use of these bioflavonoids for venous disorders. The mechanism involves anti-inflammatory actions, antioxidant effects, and the improvement of lymphatic drainage.

However, the term "bioflavonoid (unspecified)" is nonspecific, and not all bioflavonoids have been equally studied for venous support. The evidence is most robust for certain types like diosmin and hesperidin, while evidence for other flavonoids is either limited or lacking. Overall, scientific evidence supports the use of specific bioflavonoids for venous health, but the generalization to all bioflavonoids is not fully justified based on current research.

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