Evidence supporting the use of: Vitexicarpin
For the body system: Uterus

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Vitexicarpin, also known as casticin, is a flavonoid compound found in the fruits of Vitex agnus-castus (chaste tree). The use of Vitex agnus-castus in herbal medicine for supporting the uterus and alleviating women’s reproductive health issues—such as premenstrual syndrome (PMS), menstrual irregularities, and other gynecological conditions—has a long tradition, especially in European and Mediterranean folk medicine. The rationale for this use is primarily based on the purported effects of Vitex on hormonal balance, particularly its ability to modulate prolactin and support the luteal phase of the menstrual cycle. However, while the plant extract as a whole has some clinical studies supporting its use for PMS and related symptoms, the evidence specifically for Vitexicarpin as the active constituent is limited and largely preclinical. Most scientific research on Vitexicarpin focuses on its anti-inflammatory, antioxidant, and potential anticancer properties rather than direct effects on uterine health. Therefore, its use for supporting the uterus is justified primarily by traditional usage, with only weak scientific evidence specific to Vitexicarpin itself.

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