False Unicorn (Chamaelirium luteum) has a long-standing history of use in traditional herbal medicine, particularly among Native American and early European-American herbalists, for supporting female reproductive health. Traditional practitioners have used the root of False Unicorn to address a range of gynecological issues, such as menstrual irregularities, uterine prolapse, and symptoms associated with menopause. It was often considered a "uterine tonic," believed to help tone and strengthen the uterus and support overall reproductive function.

Despite its popularity in historical herbal practices, there is a significant lack of modern scientific evidence to validate these claims. There are no well-controlled human studies, and only sparse preclinical data exist regarding its pharmacology or active constituents relevant to uterine health. Most of the information available comes from 19th and early 20th-century herbal texts and anecdotal reports, rather than peer-reviewed research. Regulatory bodies such as the FDA have not recognized False Unicorn as effective for any uterine or reproductive condition.

In summary, while False Unicorn's use for uterine support is well-documented in tradition, there is insufficient scientific validation to support these uses by modern evidence-based standards.