Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins, particularly those derived from cranberries, are supported by a moderate level of scientific evidence for their potential role in supporting urinary tract health and helping to prevent urinary tract infections (UTIs). The active component believed to be responsible is the A-type proanthocyanidin, which is distinct from the more common B-type found in many other plants. A-type proanthocyanidins have been shown in laboratory studies to inhibit the adhesion of Escherichia coli (E. coli) — the primary causative agent of UTIs — to the epithelial cells lining the urinary tract. By preventing bacterial adherence, these compounds may reduce the likelihood of infection development.

Several randomized controlled trials and meta-analyses have evaluated cranberry products (as a source of proanthocyanidins) for UTI prevention, with results suggesting a modest but significant benefit, especially in women with a history of recurrent UTIs. However, the evidence is not uniformly positive; some studies have failed to show a significant effect, possibly due to variability in proanthocyanidin content, formulation, and dosage. Systematic reviews, such as those from the Cochrane Collaboration, conclude that cranberry products (and thus proanthocyanidins) may reduce recurrence of UTIs, but the evidence is not strong enough for definitive clinical recommendations.

In summary, there is scientific rationale and moderate-quality evidence supporting the use of proanthocyanidins in UTI prevention, but further standardized research is needed to clarify their efficacy, optimal dose, and formulation.

More about Proanthocyanidin (unspecified)
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Other ingredients used for Urinary Tract Infections

Other health conditions supported by Proanthocyanidin (unspecified)

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