Evidence supporting the use of: Proanthocyanidin
For the health condition: Urinary Tract Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins, particularly those found in cranberries (Vaccinium macrocarpon), are supported by scientific research for their role in the prevention (not treatment) of urinary tract infections (UTIs). The active compounds, A-type proanthocyanidins, are believed to inhibit the adhesion of Escherichia coli (E. coli) bacteria to the urothelial cells lining the urinary tract, thereby reducing the likelihood of infection. Several randomized controlled trials and meta-analyses have examined cranberry products for UTI prevention, with mixed but generally positive results suggesting a modest benefit, especially in women with recurrent infections. Meta-analyses published in journals such as Cochrane Database of Systematic Reviews and JAMA indicate that cranberry products may reduce the incidence of UTIs compared to placebo, though the effect size is moderate and not all studies agree.

However, it is important to note that the evidence does not strongly support the use of proanthocyanidins for the treatment of active UTIs; rather, the benefit is primarily seen in prevention. The precise dosage and formulation required for efficacy are still under investigation, and not all cranberry or proanthocyanidin supplements provide the effective A-type compounds. Most clinical guidelines suggest cranberry products as an adjunct preventive measure, not as a substitute for antibiotic therapy in active infections. In summary, while scientific evidence supports a role for proanthocyanidins in UTI prevention, the strength of evidence is moderate, and their use is not recommended for treating existing UTIs.

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Products containing Proanthocyanidin

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