Evidence supporting the use of: Hydroxyquinoline
For the health condition: Urinary Tract Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Hydroxyquinoline (often referring to 8-hydroxyquinoline or its derivatives) has been used historically as an antimicrobial agent, including for the treatment of urinary tract infections (UTIs). Its use dates back to the early to mid-20th century, when it was common in Europe and some parts of Asia to prescribe hydroxyquinoline derivatives (such as nitroxoline) for uncomplicated lower UTIs. The rationale for its use was primarily its broad-spectrum antimicrobial activity, particularly against some gram-negative bacteria commonly implicated in UTIs. However, the evidence base for its efficacy is limited by the lack of robust, modern clinical trials. Most data come from small, older studies and case reports, and there is little high-quality evidence comparing hydroxyquinoline derivatives to standard-of-care antibiotics used today. Furthermore, concerns regarding resistance and potential toxicity (especially with long-term use or high doses) have led to a decline in its use in many countries. Current clinical guidelines generally do not recommend hydroxyquinoline or 8-hydroxyquinoline derivatives as first-line therapy for UTIs. In summary, the use of hydroxyquinoline for UTIs is justified more by historical precedent than by strong scientific validation, and it is largely of historical interest rather than a contemporary standard of care.

More about Hydroxyquinoline
More about Urinary Tract Infections

Other health conditions supported by Hydroxyquinoline

Athlete's Foot
Skin (infections)
Urinary Tract Infections

Products containing Hydroxyquinoline

We currently have no products on Caring Sunshine that contain this ingredient.