Little ironweed (Vernonia cinerea) has a well-established role in traditional medicine systems across Asia, especially in Ayurveda, Thai, and folk medicines. It is traditionally used to manage urinary disorders including dysuria (painful urination), urinary tract infections, and as a mild diuretic to support urinary health. Folk remedies often employ the whole plant or specific parts (leaves, stems) in decoctions or infusions believed to facilitate urination and "cleanse" the urinary tract. The rationale is rooted in the concept of promoting urinary flow and alleviating symptoms linked to mild urinary dysfunction.

However, the scientific evidence supporting these uses is limited. A few preclinical studies have suggested mild diuretic and anti-inflammatory effects in animal models, but robust human clinical trials are lacking. Most research on Vernonia cinerea focuses on its antioxidant, anti-inflammatory, and potential anti-smoking properties rather than direct effects on the urinary system. Thus, while its use is justified by tradition, and some pharmacological activities may indirectly support urinary health, there is insufficient scientific validation at this time.