Synopsis

Source of validity: Scientific
Rating (out of 5): 2

S-Methylmethionine (SMM), also known as vitamin U, has been investigated primarily for its potential gastroprotective properties, particularly in the context of peptic ulcers. The compound was first isolated from cabbage juice, and early clinical and experimental studies from the mid-20th century suggested that SMM could accelerate the healing of gastric and duodenal ulcers. Mechanistically, SMM is thought to support mucosal protection by stimulating mucus production, enhancing cell proliferation, and possibly reducing gastric acid secretion. However, much of the clinical research is dated, often lacking the rigorous methodologies and controls seen in contemporary trials.

Recent research, mostly in animal models, has provided additional support for SMM's protective effects against chemically induced gastric mucosal injury. These studies propose that SMM may reduce oxidative stress and inflammation in the gastric lining. However, robust, high-quality, placebo-controlled human trials are lacking, and SMM has not been widely adopted into mainstream medical practice for ulcer treatment. It is sometimes encountered in dietary supplements or as an alternative therapy, especially in Eastern Europe and Russia.

In summary, while some scientific evidence exists—mainly from early clinical work and more recent animal studies—the quality and quantity of evidence are limited. Thus, the current scientific validation for SMM’s use in ulcer treatment is modest, justifying a rating of 2 out of 5.

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