Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oleanolic acid, a naturally occurring triterpenoid found in various plants, has been traditionally used in herbal medicine, especially in Asian countries, for a variety of ailments including liver disorders and inflammatory conditions. Regarding ulcers, particularly gastric or peptic ulcers, there is emerging scientific evidence supporting its potential protective effect. Several preclinical studies (in vitro and animal models) indicate that oleanolic acid can reduce gastric mucosal damage induced by factors such as ethanol, NSAIDs, or stress. The mechanisms proposed include its antioxidant activity, enhancement of mucosal defense, reduction of gastric acid secretion, and anti-inflammatory effects. For instance, animal studies have shown that oleanolic acid pretreatment can significantly decrease ulcer indices and increase gastric mucus production. However, the evidence is still limited to preclinical research; there is a lack of robust clinical trials in humans. No major regulatory body currently recognizes oleanolic acid as a standard treatment for ulcers. While the scientific basis is promising and provides a rationale for further research, the current level of evidence does not support widespread clinical use. Therefore, oleanolic acid’s use for ulcer support is scientifically justified at an experimental level, but not established in clinical practice.

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