Neem (Azadirachta indica) has a long history of use in traditional medicine, particularly in Ayurveda and Unani systems, for various gastrointestinal disorders, including ulcers. However, in recent decades, scientific research has begun to investigate and validate some of these traditional claims. Several animal studies have demonstrated that neem leaf and bark extracts possess gastroprotective and anti-ulcer properties. The proposed mechanisms include inhibition of gastric acid secretion, enhancement of mucosal defense factors, antioxidant effects, and anti-inflammatory actions. For example, a study published in the journal Life Sciences (2004) showed that neem bark extract reduced ulcer formation in rats subjected to various ulcer-inducing agents, such as stress and NSAIDs. Additionally, neem extracts have been shown to increase the secretion of gastric mucus, which helps protect the stomach lining from acid and pepsin damage.

Despite these promising preclinical findings, high-quality human clinical trials are limited. Most evidence still comes from animal models or in vitro studies, and there is a lack of large-scale, randomized controlled trials in humans to definitively establish neem’s efficacy and safety for treating gastric or duodenal ulcers. Nevertheless, the available data suggest that neem possesses potential anti-ulcer activity, providing a scientific basis for its traditional use. As always, individuals should consult healthcare professionals before using neem for ulcer management, especially due to possible side effects or interactions with conventional medications.