Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus paracasei is a probiotic bacterium that has been studied for its potential gastrointestinal benefits, including the management of ulcers, particularly those associated with Helicobacter pylori infection. The scientific rationale for its use centers on its ability to modulate the gut microbiota, enhance mucosal barrier function, and exert anti-inflammatory effects. Several in vitro and animal studies suggest that L. paracasei can inhibit the growth of H. pylori, the primary bacterial cause of peptic ulcers, and reduce associated inflammation. Some small human clinical trials have shown that supplementation with L. paracasei may help reduce gastric mucosal damage and improve eradication rates when used alongside standard antibiotic therapy for H. pylori infection.

However, the overall quality of the evidence is moderate at best. Most clinical studies are small and often use multi-strain probiotic formulations, making it difficult to isolate the effects of L. paracasei alone. There is some evidence for symptomatic relief (e.g., reduced dyspepsia, improved gut comfort), but strong, large-scale randomized trials demonstrating a direct effect on ulcer healing are lacking. Therefore, while there is a scientific basis and some preliminary clinical support for the use of L. paracasei in ulcer management, the evidence is not robust, and it is best considered as an adjunct to established medical therapies rather than a standalone treatment.

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