Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus fermentum has been studied for its potential role in supporting or treating ulcers, particularly peptic ulcers, due to its probiotic properties. The primary scientific rationale centers around its ability to modulate the gut microbiota, enhance mucosal barrier function, and inhibit the growth of Helicobacter pylori, a key pathogen implicated in the development of gastric and duodenal ulcers. Several in vitro and animal studies have demonstrated that L. fermentum can reduce inflammation, improve mucosal healing, and decrease colonization of H. pylori. There are also a few small clinical studies suggesting that supplementation with L. fermentum may help reduce ulcer symptoms and improve eradication rates when used alongside standard antibiotic therapies. However, the number of high-quality human trials is limited, and much of the evidence comes from related Lactobacillus species rather than L. fermentum specifically. As such, while the use of L. fermentum for ulcer support is grounded in emerging scientific research, the overall strength of evidence remains moderate to low (rated 2 out of 5), and further rigorous clinical trials are needed to confirm efficacy and safety in this context.

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