Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Catechin gallate is a type of polyphenol found in green tea and some other plants. There is emerging scientific evidence suggesting that catechin gallate and related catechins may have a beneficial effect in the context of gastric ulcers, mostly based on preclinical studies. Several in vitro and animal studies have shown that catechins, including catechin gallate, possess antioxidant, anti-inflammatory, and antimicrobial properties. Notably, some studies have indicated that catechins can inhibit Helicobacter pylori, a bacterium strongly linked to the development of gastric ulcers in humans (Matsubara et al., 2003).

Additionally, animal models have demonstrated that catechin gallate may help protect the gastric mucosa from damage due to ethanol or stress by modulating oxidative stress and inflammatory responses (Rasheed et al., 2009). However, robust clinical trials in humans are lacking, and there is insufficient evidence to recommend its use as a standalone treatment or preventive agent for ulcers in clinical practice. The current support is primarily mechanistic and preclinical, with a low evidence rating due to the absence of well-controlled human trials. More research is needed to determine efficacy, dosing, and safety in the context of ulcer management.

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