Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acemannan is a major polysaccharide component found in the inner leaf gel of Aloe vera. Its use for treating or supporting ulcers, particularly gastric and peptic ulcers, is primarily supported by preclinical scientific studies rather than long-standing traditional use. Several in vitro and animal studies have demonstrated that Acemannan possesses anti-inflammatory, immunomodulatory, and wound healing properties. These effects are thought to contribute to the repair of gastric mucosa and reduction of ulceration, likely through promoting cellular proliferation, stimulating macrophage activity, and enhancing mucosal barrier function. Some studies have shown that Acemannan can reduce the size of experimentally induced gastric ulcers in rats and may protect against ulcer formation by modulating inflammatory cytokines and oxidative stress markers.

However, robust clinical evidence in humans is currently lacking. Most of the data come from animal models or cell culture studies, with very few small-scale human trials evaluating the efficacy of oral or topical Aloe vera preparations (which contain Acemannan among other compounds) for ulcer healing. The mechanism of action is still not fully elucidated and the specific contribution of Acemannan compared to other Aloe vera constituents remains under investigation. Therefore, while there is a scientific rationale and some preliminary evidence supporting its use for ulcers, the overall evidence level is moderate to low, and further well-designed clinical trials are needed to establish efficacy and safety in humans.

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