Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Simaruba (Simarouba amara or Simarouba glauca) has a history of traditional use for treating external ulcerations, particularly in folk medicine systems of Central and South America. Indigenous peoples have used poultices and decoctions made from the bark or leaves of Simaruba to address wounds, sores, and ulcerative skin conditions. The rationale for its use is based on observed astringent and antimicrobial properties, as well as anecdotal evidence that it promotes healing and reduces infection in open wounds and ulcers.

Despite the longstanding traditional application, there is a lack of robust clinical or pharmacological studies specifically supporting the use of Simaruba for external ulcerations. Some laboratory research has identified the presence of quassinoids and other bioactive compounds in Simaruba species, which may have antimicrobial and anti-inflammatory effects, but these findings have not been directly linked to controlled studies on wound healing or ulcer treatment in humans. As such, the evidence remains primarily anecdotal and based in ethnobotanical tradition, with scientific validation still limited. Therefore, while Simaruba continues to be used in traditional medicine for this purpose, its efficacy and safety for treating external ulcerations have not been firmly established by modern research.

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