Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sesquiterpenic acids are a class of compounds commonly found in various medicinal plants, such as those from the Asteraceae family (e.g., Arnica montana, Calendula officinalis, Inula helenium). The traditional use of these plants for treating external ulcerations, wounds, and skin irritations dates back centuries, particularly in European and Asian herbal medicine. Topical preparations made from these plants have been applied to promote healing, reduce inflammation, and prevent infection in skin lesions and ulcers.

The rationale for their use is primarily based on ethnobotanical knowledge and anecdotal evidence. Herbal manuscripts and folk medicine records often cite the application of plant extracts containing sesquiterpenic acids for skin afflictions. However, while some in vitro and animal studies suggest potential anti-inflammatory, antimicrobial, or wound-healing activities of sesquiterpenic acids, robust clinical evidence in humans remains limited. Most of the references to sesquiterpenic acids in the context of ulcerations derive from their occurrence in traditional medicinal plants rather than isolated compound studies.

In summary, the use of sesquiterpenic acid-containing plants for external ulcerations is rooted in traditional medicine practices. The direct scientific validation for sesquiterpenic acids themselves in this context is minimal, and most of the supporting evidence is historical or based on the general activity of plant extracts.

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