Pellitory-of-the-wall (Parietaria officinalis) has a long history of use in traditional herbal medicine, particularly in Europe. Historical herbal texts, such as those by Nicholas Culpeper and John Gerard, mention its application for a variety of ailments, including external ulcerations and wounds. The use of Pellitory-of-the-wall as a poultice or wash for ulcers was common in folk medicine, where it was believed to have soothing and healing properties when applied topically. The plant was often macerated and applied directly to the affected area, or used as an ingredient in ointments.

However, the evidence supporting this use is almost entirely anecdotal and based on traditional practices. There is a lack of modern clinical studies or robust pharmacological research specifically evaluating its efficacy for external ulcerations. Some phytochemical analyses have identified flavonoids and mucilage in Parietaria officinalis, which could theoretically contribute to anti-inflammatory or soothing effects, but these findings have not been translated into clinical recommendations or validated by controlled trials.

In summary, while Pellitory-of-the-wall has a traditional reputation for use in treating external ulcerations, this is not supported by contemporary scientific evidence. Its use remains rooted in historical practice rather than validated medicine.