Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Immortelle (Helichrysum italicum) has a long history of traditional use in the treatment of external ulcerations, wounds, and skin conditions. Historical herbal texts and ethnobotanical surveys from the Mediterranean region document the topical application of Immortelle extracts, infusions, or oils to support wound healing and soothe inflamed or ulcerated skin. The plant has been valued for its purported anti-inflammatory, antimicrobial, and tissue-regenerating properties. These traditional uses are largely based on empirical observations passed down through generations, rather than on rigorous scientific research.

Although some preliminary scientific studies indicate that Immortelle contains compounds (such as flavonoids, sesquiterpene lactones, and essential oils) that possess anti-inflammatory and antimicrobial activities, direct clinical evidence specifically supporting its efficacy for external ulcerations is limited. Most available studies are in vitro or in vivo (animal models) and relate to general wound healing or anti-inflammatory effects, not specifically ulcerations. As such, the evidence supporting its use for external ulcerations is primarily traditional, with a moderate level of evidence (2/5) reflecting the gap between longstanding empirical use and limited clinical validation.

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