Evidence supporting the use of: Ficin
For the health condition: Ulcerations (external)
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Ficin, a proteolytic enzyme derived from the latex of the fig tree (Ficus carica), has a longstanding history of traditional use in wound care, particularly for the treatment of external ulcerations. Historical records and ethnobotanical sources indicate that ficin-containing fig latex has been applied topically to ulcers and wounds in various traditional medicine systems, including those of the Mediterranean and Middle Eastern regions. The rationale behind this usage is primarily based on ficin's enzymatic activity, which helps in debriding necrotic tissue and promoting wound cleaning, thereby potentially facilitating the healing process.
However, rigorous scientific studies evaluating ficin specifically for external ulcerations are limited. Most available data are either anecdotal or derived from in vitro or animal studies demonstrating ficin's proteolytic and debriding properties. Clinical evidence directly supporting its efficacy and safety in treating human ulcerations is sparse. Nevertheless, the traditional use persists, and ficin or fig latex preparations are sometimes employed in folk remedies for chronic wounds and ulcers. Given the lack of robust clinical trials, the evidence rating is moderate (2/5), reflecting that while there is a plausible mechanism and historical precedent, conclusive scientific validation is lacking.
Other ingredients used for Ulcerations (external)
aloe verabisabolol
dyer’s woad root
Japanese sophora
lactoperoxidase
lauric acid
marshmallow
protease
vitamin C
zinc
rubia cordifolia
yarrow
moss
amber
birch
sheep's sorrel
assam indigo
camphor oil
stillingia
wood betony
white oak
melaleuca alternifolia
arnica
Ardisia
acacia
Agrimony
Antirrhinum majus
Achyranthes
Abrus
Alchornea
Alchemilla
Ajuga
Aucubin
American Liverleaf
Aquilegia formosa
Allantoin
Alkanet
Ampelopsis
Acemannan
Asarabacca
Abuta
Alkanna
Arisaema
Butter
Bai Ji
Baliospermum
Baphicacanthus cusia
Bleeding Heart
Black-Eyed Susan
Bloodroot
Benzoin
Borate
Bletilla
Boxwood
Comfrey
Celandine
Cranesbill
Cedrus libani
Chiococca alba
Cocklebur
Dragon's Blood
Dianthrone
European Field Elm
Echinodorus
Elaeagnus glabra
Other health conditions supported by Ficin
AbrasionsDigestion (poor)
Injuries
Sore Throat
Ulcerations (external)
Ulcers
Wounds and Sores