Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Dianthrone is a dimeric anthraquinone compound most commonly associated with plants in the genus Hypericum (St. John's Wort), where it occurs in forms such as hypericin and pseudohypericin. Its use for external ulcerations is primarily rooted in traditional medicine, especially within European herbal traditions. Historically, extracts from St. John's Wort, which contain dianthrone derivatives, have been applied topically to aid wound healing, burns, and ulcerations, owing to their purported anti-inflammatory, antimicrobial, and astringent properties. However, specific documentation or clinical trials directly evaluating isolated dianthrone compounds for external ulcerations are lacking. Most evidence is anecdotal or based on the broader use of St. John’s Wort oil or extracts in folk medicine. Some in vitro and animal studies suggest that hypericin-containing extracts may have antimicrobial and wound-healing properties, but they do not isolate dianthrone as the active agent, nor do they reach the threshold of rigorous scientific validation. Therefore, while there is a tradition of use for preparations containing dianthrone, the evidence supporting its effectiveness is limited and not robustly confirmed by modern research.

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