Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Aucubin is an iridoid glycoside found in several medicinal plants, most notably Plantago species (such as Plantago major, or broadleaf plantain). Its use for external ulcerations is primarily supported by traditional medicine, particularly in European and Asian herbal practices. Historically, poultices made from plantain leaves, which are rich in aucubin, have been applied to skin wounds, ulcers, and sores to promote healing and reduce inflammation. The rationale for this use is based on centuries of ethnobotanical knowledge rather than robust clinical studies.

Some preclinical studies and in vitro experiments suggest that aucubin exhibits anti-inflammatory, antimicrobial, and wound-healing properties, which could theoretically benefit ulcerations. However, these effects have not been validated by high-quality clinical trials directly assessing aucubin’s efficacy for external ulcers in humans. The majority of published research remains limited to laboratory or animal models, or involves whole-plant extracts rather than isolated aucubin. As such, while there is some biological plausibility, the current evidence in support of aucubin’s use for external ulcerations is primarily traditional, with a modest scientific basis that does not yet warrant a higher evidence rating.

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