Aquilegia formosa, commonly known as crimson columbine or western columbine, has a history of traditional use among various Indigenous peoples of North America. Historical ethnobotanical sources report that some Native American groups used poultices or infusions made from the crushed leaves or flowers of Aquilegia formosa to treat external ulcerations, wounds, or skin sores. These uses were primarily topical applications intended to promote healing or provide soothing relief. However, this practice was based on empirical traditional knowledge rather than on known active constituents with proven efficacy or modern scientific validation.

There is little to no modern scientific research investigating the pharmacological effects of Aquilegia formosa on skin ulcerations or wounds. No clinical trials, controlled studies, or rigorous in vitro data support its efficacy or safety for this indication. In fact, many species in the Aquilegia genus are known to contain potentially toxic alkaloids, and ingestion is not recommended. The external use in traditional contexts was likely limited and localized, and modern herbal references generally do not recommend Aquilegia formosa for any medicinal use due to safety concerns and insufficient evidence.

In summary, the use of Aquilegia formosa for external ulcerations is rooted in traditional practice but lacks scientific validation, and the evidence supporting its efficacy is weak and anecdotal.