Alchornea cordifolia, commonly known as the Christmas bush, has a long history of use in traditional African medicine, particularly for the treatment of external ulcerations and wounds. Ethnobotanical surveys from West and Central Africa consistently report the topical application of crushed leaves or leaf extracts to promote healing of skin ulcers, sores, and wounds. The plant is valued for its purported anti-inflammatory, antimicrobial, and astringent properties, which are believed to contribute to its effectiveness in wound care.

Scientific studies offer some supportive evidence, primarily in vitro and animal models. Several investigations have demonstrated that extracts of Alchornea cordifolia possess antibacterial activity against common wound pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. Additionally, some studies have shown that the extracts may enhance wound contraction and epithelialization in animal models, suggesting potential wound-healing properties. The phytochemicals present, such as flavonoids and tannins, are believed to contribute to these effects.

However, clinical studies in humans are lacking, and the bulk of the evidence remains at the traditional and preclinical research levels. Therefore, while the traditional use is well-documented and supported by some laboratory research, more rigorous clinical trials would be needed to fully validate the efficacy of Alchornea cordifolia for treating external ulcerations.