Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Andrographis paniculata, commonly known as "king of bitters," has a long history of use in Ayurvedic and traditional Chinese medicine for a variety of ailments, including infections and fever. Its use in Tuberculosis (TB) is primarily rooted in traditional medicine rather than robust scientific evidence. In some cultures, Andrographis is used as an adjunct therapy for respiratory tract infections and has been employed to provide symptomatic relief in TB, such as reducing fever and inflammation. The traditional rationale is largely based on its perceived "cooling" and anti-inflammatory effects rather than any specific anti-mycobacterial activity.

Scientifically, laboratory studies have shown that extracts of Andrographis paniculata possess general immunomodulatory and anti-inflammatory properties, and in vitro studies have indicated some antimicrobial activities against various bacteria. However, there is very limited and inconclusive research specifically addressing its efficacy against Mycobacterium tuberculosis, the causative agent of TB. No large, well-controlled clinical trials have validated its use as an effective treatment for TB. Thus, while Andrographis is traditionally used in some regions for TB-related symptoms, its use is not supported by strong scientific validation or clinical evidence in this specific context.

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