Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Abrus, typically referring to Abrus precatorius (commonly known as jequirity or rosary pea), has been cited in various traditional medical systems, including Ayurveda and folk medicine, as a remedy for respiratory ailments such as tuberculosis (TB). Historical records and ethnobotanical surveys indicate that preparations from Abrus leaves, roots, or seeds have been used in some regions as expectorants, anti-inflammatory agents, or adjuncts in the management of TB symptoms. However, these uses are primarily based on anecdotal traditional knowledge rather than rigorous clinical evaluation.

From a scientific perspective, there is minimal direct evidence supporting the efficacy or safety of Abrus species for the treatment of tuberculosis. While some laboratory studies have identified antimicrobial compounds in Abrus extracts, these findings are preliminary and do not specifically address activity against Mycobacterium tuberculosis in vivo or in clinical settings. Additionally, Abrus seeds contain abrin, a highly toxic ribosome-inactivating protein, which poses significant risks if not properly processed. No high-quality clinical trials or robust pharmacological studies validate its use for TB in humans.

In summary, the use of Abrus in tuberculosis is justified primarily by tradition, with little to no scientific validation. Its application in TB should be approached with caution due to toxicity concerns and lack of proven efficacy.

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