White mulberry (Morus alba) has been studied for its potential effects on lipid metabolism, including triglyceride levels. Several small-scale clinical studies and animal research suggest that extracts from white mulberry leaves may have a modest effect in reducing triglycerides. The primary proposed mechanism involves the inhibition of intestinal absorption of carbohydrates and fats, likely mediated by compounds such as 1-deoxynojirimycin (DNJ), which acts as an alpha-glucosidase inhibitor. By slowing the absorption of sugars and fats, white mulberry may help reduce postprandial triglyceride spikes.

A few randomized controlled trials in humans have examined the effects of white mulberry leaf supplementation on lipid profiles. Some of these studies report significant reductions in triglyceride levels when compared to placebo, although the sample sizes are typically small and study durations short. Additionally, these studies often use standardized extracts, which may differ in composition from commercial products.

Overall, the evidence supporting white mulberry’s effect on high triglycerides is limited but promising. The available data do not yet justify strong clinical recommendations, but the scientific rationale and preliminary results warrant further investigation. There is no significant traditional use of white mulberry specifically for triglycerides, as historical use focused more on diabetes and general health.