Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Niacinamide is a form of vitamin B3, closely related to niacin (nicotinic acid). However, it is important to distinguish between the two: while both are B3 vitamers, only niacin (nicotinic acid) has robust scientific evidence supporting its use in the management of high triglycerides and other lipid abnormalities. Niacin (nicotinic acid) has been shown in multiple well-conducted clinical trials to significantly lower triglyceride levels, reduce LDL cholesterol, and increase HDL cholesterol. Its lipid-lowering effect is attributed to the inhibition of hepatic diacylglycerol acyltransferase-2, leading to decreased synthesis of very-low-density lipoprotein (VLDL), a precursor of triglycerides.

Niacinamide, on the other hand, does not possess the same lipid-lowering properties. It does not significantly impact triglyceride levels, as it does not cause the same pharmacological effects on lipid metabolism as niacin. Clinical guidelines and reviews consistently recommend niacin (nicotinic acid)—not niacinamide—for hypertriglyceridemia and dyslipidemia.

In summary, while niacin (nicotinic acid) is scientifically validated and FDA-approved for treating high triglycerides, niacinamide is not used for this purpose due to a lack of efficacy. The confusion may arise from their chemical similarity, but only niacin (nicotinic acid) should be considered for triglyceride management based on current scientific evidence.

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