Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trimethylglycine (TMG), also known as betaine, has been investigated for its effects on lipid metabolism, including triglyceride levels. The rationale for its use is based on TMG’s role as a methyl donor involved in homocysteine metabolism, which is linked to cardiovascular health. Several clinical studies have examined TMG supplementation in humans, particularly in individuals with nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome, conditions often associated with elevated triglycerides.

Some research indicates that TMG supplementation can reduce homocysteine levels, but its impact on triglycerides is less clear. A few small clinical trials and animal studies suggest that TMG may actually increase plasma triglyceride levels, especially when given in high doses (e.g., Schwab et al., 2002; Steenge et al., 2003). However, other studies in patients with NAFLD have shown potential benefits, such as improvements in liver fat and lipid profiles, but results are inconsistent and not robustly replicated.

Overall, while TMG is sometimes used with the intention of supporting healthy triglyceride levels, the current scientific evidence supporting this use is weak and mixed, with some studies even raising concerns about possible adverse effects on triglycerides. Therefore, the evidence rating for TMG’s efficacy in lowering high triglycerides is low (2 out of 5), and its use for this purpose cannot be strongly recommended based on current scientific data.

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