Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tangeretin is a polymethoxylated flavone found predominantly in the peel of citrus fruits, such as tangerines and oranges. There is some scientific evidence suggesting that tangeretin may have beneficial effects on lipid metabolism, including the reduction of triglyceride levels. Most of the available evidence comes from animal and in vitro studies. For example, research in rodent models has shown that tangeretin supplementation can reduce serum triglyceride and cholesterol concentrations, possibly by modulating gene expression involved in lipid synthesis and breakdown (J Agric Food Chem. 2010;58(5):2829-35). The mechanism is thought to involve the regulation of enzymes such as HMG-CoA reductase and the activation of peroxisome proliferator-activated receptors (PPARs), which play roles in lipid metabolism. However, robust human clinical trials are lacking. The evidence in humans is limited to small studies or extrapolations from research on citrus flavonoids as a general group, rather than tangeretin specifically. Therefore, while there is a plausible scientific rationale and some preclinical data to support the use of tangeretin for reducing high triglycerides, the overall strength of the evidence is weak, and clinical recommendations cannot be firmly made at this time. Additional well-designed human studies are necessary to confirm its efficacy and safety for this purpose.

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