Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sesame seeds (Sesamum indicum) have been traditionally consumed in various cultures, but their use for lowering triglycerides has also been explored in scientific studies. The primary bioactive compounds in sesame seeds, such as lignans (sesamin and sesamolin) and unsaturated fatty acids, are hypothesized to exert lipid-lowering effects. Several small clinical trials and animal studies have indicated that sesame seed consumption or sesame oil supplementation may reduce serum triglyceride levels, likely through mechanisms involving improved lipid metabolism and antioxidant effects.

For example, a randomized controlled trial published in the Journal of Medicinal Food (2006) found that supplementation with sesame oil for 45 days led to significant reductions in total cholesterol and triglycerides in hypertensive patients. Another study in Nutrition Journal (2011) reported similar findings in type 2 diabetic patients, but with modest changes in triglycerides specifically. Animal studies have generally shown more pronounced triglyceride-lowering effects.

However, the overall quality of human evidence is limited by small sample sizes, short durations, and heterogeneous study designs. Meta-analyses suggest a possible benefit but emphasize the need for larger, well-controlled trials. Thus, while there is some scientific support for the use of sesame seed in managing high triglycerides, the evidence is not robust, and it should not replace established medical therapies.

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