Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pumpkin seed oil has been investigated for its potential effects on lipid profiles, including triglyceride levels. Several animal studies and a few small human studies suggest that pumpkin seed oil may have lipid-lowering effects. The proposed mechanism is primarily attributed to the oil’s content of phytosterols, polyunsaturated fatty acids (especially linoleic and oleic acids), and antioxidants, which may help modulate lipid metabolism and reduce oxidative stress associated with dyslipidemia.

For example, a 2015 animal study published in the journal Lipids in Health and Disease found that rats fed a high-fat diet and supplemented with pumpkin seed oil showed a reduction in serum triglyceride levels compared to controls. Another small human study in postmenopausal women (Kim et al., 2012, Climacteric) reported improvements in lipid profiles, though the effect on triglycerides was modest and not always statistically significant.

Despite these findings, the clinical evidence is limited by small sample sizes, short study durations, and often a lack of rigorous controls. No large, high-quality randomized controlled trials have definitively established pumpkin seed oil’s effectiveness in lowering high triglycerides in humans. Therefore, while there is some scientific rationale and preliminary evidence supporting its use, the overall strength of evidence is modest (rated 2/5), and more robust research is needed before recommending it as a primary intervention for high triglycerides.

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