Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pumpkin protein, derived from pumpkin seeds, has gained attention for its potential lipid-lowering effects, including on triglyceride levels. Several small-scale studies and animal models suggest that pumpkin seed extracts and proteins may have beneficial effects on lipid profiles. For example, research in animals has shown reductions in serum triglycerides and total cholesterol after administration of pumpkin seed protein or oil. These effects are thought to be due to the high content of unsaturated fatty acids, phytosterols, antioxidants, and fiber present in pumpkin seeds, all of which may contribute to improved lipid metabolism.

However, direct clinical evidence in humans specifically using pumpkin protein to lower high triglycerides is limited. Most human studies involve pumpkin seed oil or whole seeds, with mixed results regarding triglyceride lowering. The protein fraction itself has been less studied. Therefore, while there is a scientific rationale and some preliminary evidence—mainly from animal studies and related pumpkin seed components—the evidence base is not robust, and more high-quality clinical trials are needed to establish efficacy in humans with hypertriglyceridemia.

In summary, the use of pumpkin protein for high triglycerides is supported by some scientific studies, mostly preclinical, but human data are lacking and the overall evidence is currently considered weak.

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