Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polymethoxylated flavones (PMFs) are a group of flavonoids found mainly in the peels of citrus fruits such as oranges and tangerines. Their use for supporting or treating high triglycerides is primarily supported by scientific evidence from preclinical and some clinical studies, rather than by traditional medical systems. Several animal studies have shown that PMFs, particularly compounds like nobiletin and tangeretin, can significantly reduce plasma triglyceride levels. The proposed mechanisms involve inhibition of hepatic triglyceride synthesis and improvement of lipid metabolism via modulation of key enzymes and gene expression involved in lipid homeostasis.

A limited number of small human clinical trials suggest that dietary supplementation with citrus PMFs may help lower triglyceride and cholesterol levels in individuals with hyperlipidemia. For example, a double-blind, placebo-controlled study (He et al., 2017) found that a PMF-rich extract reduced serum triglycerides after 8 weeks of supplementation. However, these studies are generally small and short-term, and larger, long-term human trials are lacking.

Overall, while there is promising preclinical evidence and some early clinical data suggesting PMFs may help lower high triglyceride levels, the strength of the current human evidence is moderate. More robust, long-term clinical trials are needed to fully establish their efficacy and safety for this purpose.

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