Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pantethine is the active form of vitamin B5 (pantothenic acid) and has been investigated for its effects on lipid metabolism, especially triglycerides. Several clinical trials and meta-analyses provide evidence that pantethine supplementation can reduce elevated triglyceride levels. The proposed mechanism involves pantethine serving as a precursor to coenzyme A, which plays a central role in fatty acid metabolism, potentially enhancing the breakdown of triglycerides and inhibiting their synthesis in the liver.

A 2014 randomized, double-blind, placebo-controlled study published in Nutrition Research demonstrated that 600 mg/day of pantethine over 16 weeks significantly reduced triglyceride levels in participants with low to moderate cardiovascular risk. Other studies and meta-analyses report triglyceride reductions in the range of 10-20% in hyperlipidemic patients. The evidence base is moderate, with small to medium-sized studies consistently showing benefit, though sample sizes are often limited, and longer-term outcomes (such as impact on cardiovascular events) remain unclear.

Guidelines from major medical organizations do not currently include pantethine as standard therapy, but it is sometimes used as an adjunct or alternative for individuals who cannot tolerate statins or other lipid-lowering medications. Overall, the use of pantethine for high triglycerides is supported by moderate-quality scientific evidence, though larger and longer studies would be beneficial to confirm its efficacy and safety profile.

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