Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Panax ginseng has been investigated for its potential effects on lipid metabolism, including triglyceride levels. Several clinical studies and animal experiments suggest that Panax ginseng may have modest triglyceride-lowering effects. Some randomized controlled trials (RCTs) have reported that ginseng supplementation can reduce serum triglyceride concentrations, likely through mechanisms involving improved insulin sensitivity, enhanced lipid metabolism, and antioxidant effects. However, the overall quality and size of these studies are generally limited, with many being small, short-term, or lacking rigorous controls.

A 2016 meta-analysis of RCTs examining ginseng’s effects on lipid profiles concluded that while there is some evidence for a beneficial effect on triglycerides, the results are inconsistent, and the reductions observed are generally modest. The proposed mechanisms include modulation of peroxisome proliferator-activated receptors (PPARs), which are involved in fat metabolism, and the inhibition of intestinal lipid absorption. Traditional medicine systems, such as Traditional Chinese Medicine, also use ginseng for general metabolic support, but its specific historical use for hypertriglyceridemia is not well documented.

In summary, while there is some scientific evidence that Panax ginseng may help lower triglycerides, the effect size appears small and the evidence is not robust. Larger, higher-quality trials are needed to clarify its efficacy. As such, the scientific evidence supporting its use for high triglycerides can be rated as low to moderate.

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