Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Omega Blend supplements typically contain a mix of omega-3 fatty acids, most commonly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), often derived from fish oil or algal oil. The use of omega-3 fatty acids to support or lower high triglyceride levels is well-supported by scientific evidence. Numerous randomized controlled trials and meta-analyses have shown that supplementation with EPA and DHA can significantly reduce serum triglyceride levels in individuals with hypertriglyceridemia. For example, a 2017 scientific advisory from the American Heart Association concluded that treatment with 4 grams per day of prescription EPA and DHA lowers triglycerides by 20-30% in most studies. The mechanism is believed to involve decreased hepatic production of triglyceride-rich very-low-density lipoproteins (VLDL). Omega-3 fatty acids are incorporated into cell membranes and may also modulate gene expression involved in lipid metabolism.

It’s important to note that while dietary supplements with lower doses (1 gram or less) may have modest effects, higher, prescription-strength doses are required for significant triglyceride reduction. Over-the-counter Omega Blend products may vary in EPA/DHA content and purity. Nonetheless, the scientific foundation for the use of omega-3 fatty acids to manage high triglycerides is robust, and this application is recognized by major medical organizations and guidelines.

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