Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacin (vitamin B3) is scientifically validated as a therapy to lower high triglycerides. Its use is supported by decades of clinical research and clinical practice guidelines. Niacin works by inhibiting hepatic diacylglycerol acyltransferase-2, which reduces the synthesis of very-low-density lipoprotein (VLDL), a precursor to triglycerides. As a result, niacin significantly lowers serum triglyceride levels—often by 20-50%—and can also modestly increase HDL (good cholesterol) and lower LDL (bad cholesterol). Numerous randomized controlled trials, including large studies such as the Coronary Drug Project and the AIM-HIGH trial, have shown that niacin effectively reduces triglyceride levels in patients with hyperlipidemia and mixed dyslipidemia.

However, while niacin is effective for lipid modification, more recent studies have called into question its benefit on cardiovascular outcomes when added to statin therapy, especially given its side-effect profile (notably flushing, glucose intolerance, and hepatotoxicity). Despite this, its triglyceride-lowering efficacy is not disputed, and it remains an option for selected patients unable to tolerate first-line medications or with particularly severe hypertriglyceridemia at risk of pancreatitis. In summary, niacin’s use to reduce high triglycerides is strongly supported by scientific evidence, though its place in therapy is now more selective due to side effects and newer alternatives.

More about niacin (vitamin B3)
More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
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arjun tree
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ashwagandha
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daidzin
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DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
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fish protein
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fruit and vegetable blend (proprietary)
genistein
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green tea
guar gum
guggul
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hesperetin
hibiscus
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lycopene
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maqui berry
matcha
naringin
niacin (vitamin B3)
oat
oleanolic acid
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olive
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oyster mushroom
palmitoleic acid
pantethine
perilla
phospholipids
pine bark
plant sterols
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resveratrol
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almond fruit
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jiaogulan
lingzhi
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