Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Guggulsterone is primarily used to support or treat high triglyceride levels based on traditional use, especially in Ayurvedic medicine. The resin from the Commiphora mukul tree, known as guggul, has been used for centuries in India for various lipid disorders, including hypertriglyceridemia. Traditional Ayurvedic texts describe guggul as a remedy for "medoroga" (obesity and lipid disorders), and it remains a popular herbal intervention in India for managing abnormal lipid profiles.

Modern scientific studies have investigated guggulsterone, the active component of guggul, for its lipid-lowering potential. Some early Indian clinical trials in the 1980s and 1990s indicated moderate triglyceride and cholesterol-lowering effects. However, more recent and larger placebo-controlled trials outside India (e.g., Szapary et al., 2003, JAMA) have not consistently confirmed these benefits and, in some cases, have reported no significant effect or even adverse changes in lipid profiles. The mechanism proposed involves modulation of nuclear hormone receptors such as FXR, which may influence bile acid and lipid metabolism.

Overall, the primary justification for using guggulsterone for high triglycerides is traditional, with limited and inconsistent scientific validation. Thus, while it is traditionally used, the scientific evidence supporting its efficacy is not strong or consistent.

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