Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fish peptides, which are bioactive protein fragments derived from fish, have been investigated in some scientific studies for their potential effects on lipid metabolism, including their ability to lower triglyceride levels. The proposed mechanisms involve inhibition of enzymes related to lipid synthesis, improvement of lipid oxidation, and modulation of metabolic pathways. Several animal studies and a limited number of small human clinical trials suggest that supplementation with fish protein hydrolysates or specific fish peptides may modestly reduce blood triglyceride concentrations. For example, some studies have reported triglyceride reductions in subjects consuming fish protein hydrolysates compared to controls, possibly due to the peptides’ influence on liver lipid metabolism and enhanced clearance of triglycerides from the bloodstream.

However, the evidence is still preliminary. Most human studies are small, short in duration, and sometimes methodologically limited. Systematic reviews and meta-analyses of fish protein supplements indicate possible but not definitive benefits for triglyceride lowering. Most clinical guidelines do not currently recommend fish peptides specifically for triglyceride management, focusing instead on dietary fish intake or omega-3 fatty acids (EPA/DHA), which have stronger evidence. In summary, while there is some scientific rationale and limited evidence supporting the use of fish peptides to help manage high triglycerides, this evidence is not robust and requires further confirmation in larger, well-designed clinical trials.

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