Evidence supporting the use of: Vitamin A (not specified)
For the body system: Thymus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A is scientifically validated to play a critical role in supporting the immune system, including the function of the thymus, which is a central organ in T-cell development. Vitamin A is essential for the maintenance and differentiation of epithelial tissues and for the regulation of immune responses. Deficiency in vitamin A has been shown to result in atrophy of the thymus, decreased numbers of circulating T cells, and impaired immune responses. Animal studies have demonstrated that vitamin A supplementation can restore thymus size and function in deficient states. In humans, while outright deficiency is rare in developed countries, populations with inadequate vitamin A intake are at higher risk for infectious diseases, partly due to compromised thymic and immune system function. Vitamin A regulates gene expression involved in lymphocyte proliferation and differentiation, and its active metabolite, retinoic acid, is crucial for the development of both central (thymic) and peripheral immune tolerance. Clinical reviews and experimental studies have repeatedly confirmed vitamin A’s indispensable role in thymic health and T-cell mediated immunity, providing a strong scientific basis for its use in supporting the thymus and overall immune function.

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