Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycerol monolaurate (GML), also known as monolaurin, has been investigated for its antimicrobial properties, including activity against Candida albicans, the main causative agent of thrush (oral or vaginal candidiasis). Several in vitro studies have demonstrated that GML can inhibit the growth of various fungi, including Candida species, by disrupting microbial cell membranes and interfering with biofilm formation. These findings suggest a potential mechanism by which GML might help manage thrush. However, most of the evidence to date is preclinical, coming from laboratory or animal studies rather than human clinical trials. There is a lack of robust, peer-reviewed clinical research directly evaluating GML's efficacy in treating or preventing thrush in humans. Some topical and dietary supplement formulations containing GML are marketed for yeast infections, but these uses are based largely on extrapolation from laboratory data rather than confirmed clinical outcomes. In summary, while there is a scientific rationale and some laboratory evidence supporting the antifungal activity of GML against Candida species, there is currently insufficient high-quality clinical evidence to strongly validate its use for treating thrush. Thus, the scientific evidence rating is moderate to low.

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