Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus acidophilus is a probiotic bacterium that has been studied for its potential to support the management of oral candidiasis (thrush), which is primarily caused by overgrowth of Candida albicans. The rationale for its use is based on its ability to help restore the balance of normal oral and gut flora, potentially inhibiting the growth of pathogenic yeasts via competitive exclusion and the production of antimicrobial substances such as lactic acid and bacteriocins.

Several small clinical studies and randomized controlled trials have explored the effect of L. acidophilus supplementation in reducing symptoms or recurrence of thrush, particularly in populations at risk, such as denture wearers and individuals receiving antibiotics or immunosuppressive therapy. Some studies have reported reduced colonization of Candida and improvement in symptoms with probiotic use, but the quality and size of these trials are limited, and results are sometimes inconsistent.

Systematic reviews and meta-analyses suggest that while probiotics may offer some benefit as an adjunct to conventional antifungal therapy, the evidence is not robust enough to recommend them as a standalone treatment. Guidelines from major health organizations do not currently endorse L. acidophilus as a primary therapy for thrush, but acknowledge that it may help in prevention or as a complementary approach. Therefore, the use of acidophilus for thrush is scientifically plausible and somewhat supported by preliminary evidence, but more rigorous research is needed to draw firm conclusions.

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