Evidence supporting the use of: Snake venom
For the health condition: Thrombosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Snake venom has been studied for its potential therapeutic applications in thrombosis due to its complex mixture of bioactive proteins and enzymes that affect blood coagulation and platelet aggregation. Several components derived from snake venom, such as ancrod (from the Malayan pit viper Calloselasma rhodostoma), batroxobin (from Bothrops atrox), and defibrinogenating agents, have demonstrated anticoagulant or thrombolytic properties in preclinical and clinical studies. These agents work by degrading fibrinogen, inhibiting platelet aggregation, or directly dissolving clots, which are mechanisms beneficial in the management of thrombotic disorders.

Ancrod, for example, was investigated in clinical trials for the treatment of deep vein thrombosis, stroke, and other thrombotic conditions. Some studies showed that ancrod could reduce blood viscosity and prevent thrombosis, though concerns about bleeding risks and inconsistent efficacy led to its withdrawal from the market. Other venom-derived compounds, such as eptifibatide (a synthetic peptide modeled after a component of rattlesnake venom), have been approved for clinical use as antiplatelet agents in acute coronary syndrome and during certain cardiac procedures.

Overall, there is scientific interest and moderate evidence for the use of snake venom derivatives in thrombosis treatment, primarily based on their mechanisms of action and results from both animal studies and some human clinical trials. However, limitations in safety and the development of safer synthetic alternatives have restricted the widespread use of natural snake venom products in clinical practice.

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Products containing Snake venom

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