Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl-L-Tyrosine (ALT) is a modified form of the amino acid L-tyrosine, which is a precursor to several important neurotransmitters, including dopamine, norepinephrine, and epinephrine. The rationale for using ALT to support cognitive function, especially in cases of "cloudy thinking" or mental fatigue, is based on its role in supporting neurotransmitter synthesis under stress or conditions of neurotransmitter depletion. Some scientific studies, primarily using L-tyrosine rather than the acetylated form, have shown that supplemental tyrosine can improve aspects of cognitive performance, such as working memory and attention, particularly in situations involving acute stress, sleep deprivation, or multitasking.

Acetyl-L-Tyrosine is thought to be more bioavailable than regular L-tyrosine, but direct comparative studies are lacking. The evidence supporting its use for general "cloudy thinking" is limited and mostly extrapolated from studies with L-tyrosine. There are few clinical trials specifically investigating ALT for cognitive enhancement in healthy adults or for chronic brain fog. The existing evidence is rated as modest (2/5) because while there is a plausible mechanism and some supporting data from related compounds, high-quality, large-scale trials directly assessing ALT for brain fog or persistent cloudy thinking are lacking. Therefore, while there is scientific interest and some preliminary support, the evidence base is not robust.

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