Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Tribuloside is a flavonoid glycoside found in plants such as Tribulus terrestris. The use of Tribulus terrestris (and thus, by extension, some of its constituents) to support male vitality, libido, and purportedly testosterone levels has roots in traditional medicine, particularly in Ayurveda and Traditional Chinese Medicine. However, the evidence for its efficacy in increasing testosterone is weak and inconsistent.

There is no high-quality, direct scientific evidence that tribuloside itself can raise testosterone in humans. Most clinical studies have investigated whole plant extracts of Tribulus terrestris, not isolated tribuloside. These studies generally show little to no significant effect on testosterone levels in healthy men, though some improvements in libido or subjective well-being have been reported. The mechanism by which tribuloside might influence testosterone remains speculative and unproven.

In summary, the use of tribuloside for supporting testosterone is based primarily on traditional use of the parent herb, not on strong scientific validation or direct evidence for tribuloside itself. The overall quality of evidence is low (rated 1 out of 5), and current research does not support a clear benefit for testosterone enhancement.

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