Evidence supporting the use of: Human Chorionic Gonadotropin
For the health condition: Testosterone (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Human Chorionic Gonadotropin (hCG) for Low Testosterone: Evidence Synopsis

Human Chorionic Gonadotropin (hCG) is scientifically validated for use in supporting or treating low testosterone levels, particularly in men with secondary hypogonadism. hCG is a hormone structurally similar to luteinizing hormone (LH), which is naturally produced by the pituitary gland and stimulates the Leydig cells in the testes to produce testosterone.

Clinical studies and guidelines support the use of hCG for men who wish to maintain fertility while being treated for low testosterone. Unlike exogenous testosterone therapy, which can suppress the hypothalamic-pituitary-gonadal (HPG) axis and decrease intratesticular testosterone production (leading to reduced sperm production), hCG stimulates endogenous testosterone production and helps preserve spermatogenesis.

Randomized controlled trials and observational studies have demonstrated that hCG can increase serum testosterone levels in men with hypogonadotropic hypogonadism and in some cases in men with idiopathic infertility. The Endocrine Society and American Urological Association both mention hCG as a treatment option for men with low testosterone who desire fertility preservation.

However, hCG is not typically the first-line therapy for primary hypogonadism (testicular failure), as its effectiveness relies on functional Leydig cells. The evidence for its use in other contexts, such as in healthy men or for "boosting" testosterone in athletes, is limited and not recommended by clinical guidelines.

In summary, hCG has a strong scientific foundation (evidence level 4/5) for treating certain forms of low testosterone, especially where fertility preservation is desired.

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