Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eurycomanone is a quassinoid compound found in the roots of Eurycoma longifolia, commonly known as Tongkat Ali or Longjack. Traditionally, Eurycoma longifolia has been used in Southeast Asian medicine as an aphrodisiac and remedy for male reproductive health. More recently, scientific interest has focused on its role in supporting testosterone levels. Several preclinical (animal and in vitro) studies have demonstrated that eurycomanone can stimulate testosterone production, primarily by increasing the release of free testosterone and inhibiting aromatase, the enzyme that converts testosterone to estrogen. Some small-scale human clinical trials have shown modest increases in testosterone among men with low baseline levels after supplementation with Eurycoma longifolia extracts standardized to eurycomanone content.

However, the overall quality of evidence is limited. Most clinical studies are small, short-term, and use whole root extracts rather than isolated eurycomanone. There is a lack of large, well-controlled, long-duration clinical trials directly assessing the effects of purified eurycomanone on testosterone in humans. Thus, while preclinical data and preliminary human studies suggest potential efficacy, the evidence is not robust. The rating of 2 reflects limited but promising scientific support, pending further research to establish efficacy and safety in larger, diverse populations.

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