Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone produced by the adrenal glands, serving as a precursor to both androgens and estrogens, including testosterone. The rationale for using DHEA to support low testosterone is based on its role in the steroidogenic pathway; theoretically, supplementing DHEA could increase downstream production of testosterone, especially in individuals with adrenal insufficiency or age-related declines in DHEA levels.

Scientific studies have found that DHEA supplementation can modestly increase serum testosterone in some populations, particularly older adults and women. However, the effect in healthy young or middle-aged men is generally small or negligible. The clinical significance of these changes is unclear. A 2015 systematic review (J Clin Endocrinol Metab, 2015) found limited evidence that DHEA supplementation increases testosterone in men, with most studies showing no significant improvement in hypogonadal symptoms, muscle strength, or well-being. In women, especially those with adrenal insufficiency, DHEA can raise testosterone levels modestly.

Overall, while there is a plausible biological mechanism and some scientific support, the evidence is inconsistent and generally weak for using DHEA as a treatment for low testosterone, particularly in otherwise healthy men. DHEA is not recommended as a first-line therapy for hypogonadism due to limited efficacy and potential side effects. Its use is better justified in specific cases, such as adrenal insufficiency, rather than as a general testosterone replacement strategy.

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